Statistical analysis The effects of independent variables on the experimental response were modeled using a second order polynomial equation with a backward, stepwise linear regression technique. The improved therapeutic efficacy could be primarily because of increased solubility and dissolution rate of FK leading to its rapid and efficient dispersion in GI tract. This study was a Pharm. The solid self-nanoemulsifying drug delivery system SNE pellets was prepared using a multi-level full factorial design. Table 1 Independent variables factors and levels for factorial design.
Conclusion The overall results of this study indicated that an improved formulation of loratadin SNEDDS pellets was successfully developed using the extrusion-spheronization technique. As we found out in this test and according to a previous study, adding the lactose had less effect on disintegration time, but would be useful to improve appearance of the pellets. In vitro dissolution profile of different pellets formulation. Find articles by Behzad Sharif Makhmalzadeh. The overall results of this study indicated that an improved formulation of loratadin SNEDDS pellets was successfully developed using the extrusion-spheronization technique. Effect of FK loading on mean globule size is shown in Fig. After 30 minutes, samples were filtered through 0.
This finding could be primarily attributed to the effects of pellet components particularly crosscarmelose on enhancing water absorption into the pellets and improve interfacial surface between liquid SNEDDS and dissolution medium.
Animals were divided into four groups of six animals each.
As we found out in this test and according to a previous study, adding the lactose had less effect on disintegration time, but would be useful to improve appearance of the pellets. The dissolution medium was ml of HCl 0. Int J Adv Pharm Sci. The pellets were dried and characterized for size sieve analysisshape image analysismechanical strength friability testdroplet tthesis laser light scattering and drug release rate dissolution test.
FK SMEDDS formulation was superior to commercial formulation with respect to in vitro dissolution profile and in vivo immunosuppressant activity. Solid self-emulsifying drug delivery system, Extrusion-spheronisation, Pellets, Loratadin. The wet mass was extruded at rpm in a screw extruder Dorsa, Iran with a die of 1mm thickness and 1mm diameter holes. The formulation was characterized as transparent to milky dispersion. Eur J Pharm Biopharm. The smedss of both Aerosil and crosscarmelose on disintegration time is shown as a surface plot Figure 2.
Author information Article notes Copyright and License information Disclaimer. Our studies demonstrated that extrusion-spheronization is a viable technology to produce self-emulsifying pellets in large scale which can improve in vitro dissolution with better solubility. Abdalla A, Mader K.
The experiments were carried out in triplicates and reported as mean droplet size and poly dispersity index PDI. FK was a gift from Glenmark Pharmaceuticals Ltd. Resulting mixtures were evaluated visually for transparency and flow properties; and by polarizing microscope for optical isotropy.
Sodium crosscarmelose was provided by Fluka, Germany and lactose was purchased from Akbarieh pharmaceutical Co Iran. The method of choice in preparing the pellet dosage forms is extrusion-spheronization since it provides so,id more benefits than other methods, including large-scale producibility, spherical shape, narrow modal size distribution, good flow, aolid of coating,6 compact packaging, higher density and surface area.
Table 1 Independent variables factors and levels for factorial design. Results obtained indicated that apart from HLB value, other factors such as structure and relative length of hydrophobic chains of surfactants had influence on microemulsification. Results and Discussion Preparation and characterization of SNE pellets Size distribution Acceptable loratadin SNE pellets were successfully prepared by extrusion-spheronization technique, using emedds factors and levels applied in this study.
It is an important prerequisite for SMEDDS, as by definition they are isotropic mixtures of oil, surfactant, and cosurfactant.
Capric acid has longer alkyl chain than that of caprylic acid. Ratio of surfactant to cosurfactant sooid selected on the basis of phase diagrams and was maintained at 2: JadhavVilasrao J. In order to view it, please contact the author of the presentation. Acknowledgments This study was a Pharm.
In this study, we intended to prepare and characterize solid self-nanoemulsifying drug delivery system for oral delivery of loratadin as the model insoluble drug. You do not have the permission to view this presentation.
These advantages of FK coupled with its long-term tolerability led to improved graft and patient survival indicating its clinical potential 3. The improved therapeutic efficacy smeds be primarily because of increased solubility and dissolution rate of FK leading to its rapid and efficient dispersion in GI tract. The effect of oil content, pH of aqueous phase, dilution, and incorporation of drug on mean globule size of resulting microemulsions was studied.
After 30 minutes, samples were filtered through 0.